Everything about Piperonyl Butoxide totally explained
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Piperonyl butoxide (
PBO) is a
pesticide synergist. It does not, by itself have pesticidal properties. However, when added to insecticide mixtures, typically
pyrethrin,
pyrethroid, and
carbamate insecticides, their potency is increased considerably.
Piperonyl butoxide is a potent
cytochrome P450 inhibitor. This family of
enzymes act as the principal detoxification pathway for many pesticides. Inhibiting the detoxification pathway allows higher unmetabolised systemic concentrations of the active insecticide to remain within the target animal for a longer period.
Piperonyl butoxide is moderately stable, and is a semisynthetic derivative of
safrole.
It is debatable whether the substance is
oncogenic,
mutagenic, or
teratogenic in humans. Its acute oral and dermal toxicity in
mammals is low, however it's toxic to fish and potentiates
rotenone.
Further Information
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